Solid lipid nanoparticles and nanostructured lipid carriers of dual functionality at emulsion interfaces. Part II: active carrying/delivery functionality

The utilisation of lipid nanostructures that can in tandem act as Pickering emulsion stabilisers and active carrier/delivery systems, could potentially enable the development liquid (emulsion-based) formulations with capacity for multi-active encapsulation delivery. Part I this work focused on first aspect two-fold functionality by investigating both solid nanoparticles (SLNs) nanostructured carriers (NLCs) to effective particles o/w emulsions. Herein, attention shifts secondary functionality, part II study assessing SLNs NLCs terms their release regulators curcumin, a model hydrophobic active. previously established physical properties particle size, zeta potential interfacial tension remained unaffected after curcumin. In emulsions, loss crystalline (solid lipid) matter presence were specifically investigated, these aspects impact upon particles’ carrying delivery performance. Low losses recorded all emulsions (ranging between 0% 15%), increasing fraction (SLNs NLCs) resulting relatively higher depletion crystallinity. Removal unadsorbed surfactant (remnant from formation processing step) prior emulsification led occupancy. Despite said changes, curcumin capacity, expressed efficiency loading did not differ an dispersion setting. Although was retained, it shown at interfaces affects rate. Partial migration oil droplet creation additional release-inducing close proximity interface are proposed be responsible overall faster expulsion. What is more, profile either or (also) stabilising microstructure, persist storage; storage (up 4 months) emulsification, 3 stabilised ‘freshly’ formed particles. Overall, present provides evidence indeed realised, markedly demonstrating concurrency does compromise one another.